Endocrine Abstracts

Introduction: Fibroblast growth factor-21 (FGF-21) is a recently discovered hormone acting as a central regulator of metabolism via adaptation of glucose homeostasis, insulin sensitivity, and ketogenesis. While acute systemic inflammatory conditions come along with profound alterations of metabolism, the role of FGF-21 in these acute phase responses is still unknown.Methods: This is a secondary analysis of two randomized, controlled trials in patients pr...

Background: Humans and other mammals need to maintain a stable core body temperature. Energy expenditure increases in response to a mild cold stimulus, this is called cold induced thermogenesis (CIT). Recently, thermogenic brown adipose tissue (BAT) has been found to play an important role for CIT in human adults. It is known that energy expenditure and CIT are acutely influenced by ambient temperature. In the present study, we investigated the effect of seasonal temperature v...